2-(2-Naphthyloxy)acetohydrazide

CAS: 36304-47-9

Ref. 3D-FN114188

Product Information

• Name: 2-(2-Naphthyloxy)acetohydrazide
• Synonyms: 2-(2-Naphthyloxy)Acetohydrazide, Acetic Acid, 2-(2-Naphthalenyloxy)-, Hydrazide

Description

2-(2-Naphthyloxy)acetohydrazide is an antibacterial and antifungal agent that belongs to the class of phenacyls. It has been shown to inhibit bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. 2-(2-Naphthyloxy)acetohydrazide also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

• Brand: Biosynth

Chemical properties

• Molecular weight: 216.24 g/mol
• Formula: C₁₂H₁₂N₂O₂
• Purity: Min. 95%
• InChI: InChI=1S/C12H12N2O2/c13-14-12(15)8-16-11-6-5-9-3-1-2-4-10(9)7-11/h1-7H,8,13H2,(H,14,15)
• InChI key: InChIKey=QSMAUHGVXYUJKN-UHFFFAOYSA-N
• SMILES: NNC(=O)COc1ccc2ccccc2c1