Product Information
NT-157 is a small-molecule drug that targets the JAK2 V617F mutation found in chronic myeloid leukemia cells. It is being investigated for its potential use as a therapy to treat cancer. NT-157 inhibits the activity of JAK2, which is an enzyme responsible for transmitting signals from outside of the cell (the extracellular environment) to inside the cell. NT-157 has been shown to be effective against cancer cells and has induced tumor regression in mice models with leukemia. The cellular targets of NT-157 are currently unknown, but it may act by disrupting microenvironmental signaling pathways or inhibiting energy metabolism in cancer cells.
NT-157 has also been shown to bind to DNA and activate transcriptional response elements that are involved in cell signaling pathways.
Chemical properties
Technical inquiry about: 3D-FN137703 NT-157
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