2-Nitrodibenzothiophene
CAS: 6639-36-7
Ref. 3D-FN26299
| 1g | To inquire | ||
| 2g | To inquire | ||
| 5g | To inquire | ||
| 10g | To inquire | ||
| 500mg | To inquire |
Product Information
- NSC 16062
2-Nitrodibenzothiophene is a nitro compound that is metabolized to benzo[a]pyrene, which is a known carcinogen. It has been shown to have cytotoxic effects on the typhimurium bacteria and induce DNA strand breaks in E. coli. 2-Nitrodibenzothiophene is also mutagenic and can cause chromosomal aberrations in mammalian cells, such as 3-methylcholanthrene. This chemical has also been found to be toxic to the liver and cause liver toxicity in mice when given at high doses. The metabolism of 2-nitrodibenzothiophene is enhanced by oxygenation, which may account for its mutagenicity profile.
2-Nitrodibenzothiophene has been shown to inhibit uptake into rat hepatocytes, decreasing the metabolic activation of this substance and leading to lower mutagenic activity and reduced cytotoxicity in rats.
Chemical properties
Technical inquiry about: 3D-FN26299 2-Nitrodibenzothiophene
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