Norharmane

CAS: 244-63-3

Ref. 3D-FN26409

Product Information

• Name: Norharmane
• Synonyms: 9H-Pyrido[3,4-b]indoleb-Carboline2,9-Diazafluorene, 2,9-Diazafluorene, 2-Azacarbazole, 9H-Pyrido[3,4-B]Indole, 9H-Pyrido[3,4-b]indol, 9H-pirido[3,4-b]indol, Carbazoline, Nsc 84417, β-Carboline, Norharman

Description

Norharmane is a polymerase chain inhibitor that prevents the transcription of DNA into RNA. It has been shown to have significant cytotoxicity against cancer cells in vitro and in vivo. Norharmane inhibits the production of cytokines, such as TNF-α and IL-1β, by inhibiting the activation of toll-like receptor 4 (TLR4). Norharmane is also known to act on other pharmacological agents, such as chemotherapeutic drugs, by inhibiting their synthesis or activity. This agent is a potential therapeutic for bowel disease because it has been shown to inhibit the release of proinflammatory cytokines from intestinal cells.

• Brand: Biosynth

Chemical properties

• Molecular weight: 168.19 g/mol
• Formula: C₁₁H₈N₂
• Purity: Min. 98 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
• InChI key: InChIKey=AIFRHYZBTHREPW-UHFFFAOYSA-N
• SMILES: c1ccc2c(c1)[nH]c1cnccc12