Noscapine hydrochloride hydrate

CAS: 912-60-7

Ref. 3D-FN30697

Product Information

• Name: Noscapine hydrochloride hydrate
• Synonyms: Narcotine hydrochloride hydrate, (5R)-5-[(1S)-4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, (5R)-5-[(1S)-4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium chloride, 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-((5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, hydrochloride, (3S)-, 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride (1:1), (3S)-, 1(3H)Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, hydrochloride, (S-(R*,S*))-, 1,3-Dioxolo[4,5-g]isoquinoline, 1(3H)-isobenzofuranone deriv., 1-alpha-Narcotine hydrochloride, Capval, Ccris 8985, Coscopin hydrochloride, Coscotabs hydrochloride, Difmetus Kapseln, Germose Noscapine, Key-tusscapine hydrochloride, Longatin, Lyobex retard, Methoxyhydrastine hydrochloride, NSC 5366 hydrochloride, Narcompren hydrochloride, Narcosine hydrochloride, Narcotine, hydrochloride, Narcotine, hydrochloride (8CI), Narcotussin, Nectadon hydrochloride, Nipaxon, Noscapine HCl, Noscapine hydrochloride, Opian hydrochloride, Opianine hydrochloride, Stilco, Teletux, Terbenol hydrochloride, Tucotine, Tulisan, Tusscapine, Tussicure P, Unii-Ttn62Ith9I, Vadebex hydrochloride, hydrogen chloride 6,7-dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one (1:1:1), l-Narcotine hydrochloride

Description

Noscapine is a drug used to treat bowel disease and as an antitussive. It is classified as a narcotic, but has no addictive properties. Noscapine inhibits the activity of nuclear dna polymerase, which prevents transcription of DNA into RNA. Its rate constant for hydrogen bonding interactions with DNA is 6 orders of magnitude slower than that of other drugs that inhibit this enzyme. Noscapine also inhibits the activity of protein kinases, which are enzymes that transfer a phosphate group from ATP to other proteins. Noscapine has been shown to bind to folate receptors on cells in culture, leading to an increase in chemiluminescence. This drug has also been shown to have anti-cancer effects on some cell lines in vitro by inhibiting the Bcl-2 protein.

• Brand: Biosynth

Chemical properties

• Molecular weight: 449.88 g/mol
• Formula: C₂₂H₂₄ClNO₇·xH₂O
• Purity: Min. 98 Area-%
• Color/Form: White Off-White Powder