(+)-Nerolidol

CAS: 40716-66-3

Ref. 3D-FN33788

Product Information

• Name: (+)-Nerolidol
• Synonyms: (6E)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol, (6E)-3,7,11-Trimethyldodeca-1,6,10-trien-3-ol, (6E)-Nerolidol, (E)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol, (E)-3,7,11-Trimethyldodeca-1,6,10-trien-3-ol, (E)-3,7,11-trimethyldodeca-1,6,10-triene-3-ol, (E)-3,7,11-trimetildodeca-1,6,10-trien-3-ol, (E)-Nerolidol, 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (6E)-, 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (E)-, 1-Geranyl-2-methyl-3-buten-2-ol, Nerolidol (E), Nerolidol B, Nerolidol trans-form, trans-Nerolidol, (±)-trans-Nerolidol

Description

Nerolidol is a natural plant product that has been shown to inhibit the growth of opportunistic fungal organisms. It has also been shown to reduce chronic cough and disease activity in animals with experimental asthma. Nerolidol is not toxic to humans, as it does not cause any adverse effects at levels up to 2000 mg/kg. In vitro studies have shown that nerolidol inhibits the enzyme activities of prostaglandin J2 (PGJ2) and cyclooxygenase-2 (COX-2). This inhibition may be due to its ability to bind with COX-1 and COX-2 enzymes, thereby preventing their activation by arachidonic acid. The molecular docking analysis of nerolidol on COX-1 has shown that it interacts with the active site of the enzyme. Furthermore, this interaction leads to the prevention of arachidonic acid from binding at the active site and consequently reduces PGJ2 production.

• Brand: Biosynth

Chemical properties

• Molecular weight: 222.37 g/mol
• Formula: C₁₅H₂₆O
• Purity: Min. 95%
• Color/Form: Colorless Clear Liquid
• InChI: InChI=1S/C15H26O/c1-6-15(5,16)12-8-11-14(4)10-7-9-13(2)3/h6,9,11,16H,1,7-8,10,12H2,2-5H3/b14-11+
• InChI key: InChIKey=FQTLCLSUCSAZDY-SDNWHVSQSA-N
• SMILES: C=CC(C)(O)CC/C=C(\C)CCC=C(C)C