Product Information
- Hsdb 7749
- Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl)
- Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
- (2E)-9-{3-[(diaminomethylidene)amino]propyl}-2-ethylidene-12-[(1E,3E)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentaazacyclononadecane-5,16-dicarboxylic acid
Nodularin is an indolic alkaloid that has been identified as a potent inhibitor of the mitogen-activated protein kinase (MAPK) pathway. It has been shown to inhibit the growth factor-β1 and platelet-derived growth factor (PDGF)-induced proliferation of vascular smooth muscle cells in vitro. Nodularin can be used to detect MAPK activation by using Western blotting with phosphorylated extracellular signal regulated kinase 1/2 (ERK1/2) antibodies. In addition, nodularin can be used for the detection of intracellular targets, such as cyclic AMP response element binding protein (CREB), which is activated by CREB-binding protein and phosphatidylinositol 3-kinase.
Chemical properties
Technical inquiry about: 3D-FN73139 Nodularin
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