Product Information
- 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-
- LL-Z 1640-2
- F 152
- L 783279
- (3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
(5Z)-7-Oxozeaenol is a natural product that inhibits the transcription factor nuclear factor kappa B (NF-κB) by binding to toll-like receptor 4. It has been shown to inhibit the growth of mesenchymal cells, leading to an increase in markers for epithelial mesenchymal transition. (5Z)-7-Oxozeaenol also induces apoptosis in breast cancer cells, specifically MDA-MB-231 cells. It activates protein kinase A and inhibits protein kinase C. This compound also inhibits the production of vasoactive intestinal peptide and TNF-α. The inhibition of these proteins leads to a decrease in cell growth and proliferation.
Chemical properties
Technical inquiry about: 3D-FO177760 (5Z)-7-Oxozeaenol
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