Oxonic acid potassium

CAS: 2207-75-2

Ref. 3D-FO26698

Product Information

• Name: Oxonic acid potassium
• Synonyms: 4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassiumAllantoxanic acid potassiumPotassium oxonate, 1,3,5-Triazine-2-carboxylic acid, 1,4,5,6-tetrahydro-4,6-dioxo-, monopotassium salt, 1,3,5-Triazine-2-carboxylic acid, 1,4,5,6-tetrahydro-4,6-dioxo-, potassium salt (1:1), 1,4,5,6-Tetrahydro-4,6-Dioxo-S-Triazine-2-Carboxylicacid,Potassiumsalt, 4,6-Dioxo-1,4,5,6-Tetrahydro-1,3,5-Triazine-2-Carboxylic Acid, 5-Azaoroticacid,Potassiumsalt, Allantoxanic Acid Potassium Salt, Allantoxanic acid, monopotassium salt, Labotest-Bb Lt00138090, Oteracil Potassium, Potassium 1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylate, Potassium 2,6-dihydroxytriazinecarboxylate, Potassium 4,6-Dihydroxy-1,3,5-Triazine-2-Carboxylate, Potassium 4,6-Dioxo-1,4,5,6-Tetrahydro-1,3,5-Triazine-2-Carboxylate, Potassium Allantoxanate, Potassium Oxonate, Potassium azaorotate, Potassium otastat, Potassium oxonate(OXO), Potassiumazaorotate, kox
• CAS: 2207-75-2

Description

Oxonic acid potassium is a selectively competitive uricase inhibitor that avoids excretion of uric acid. It also inhibits the activity of orotate phosphoribosyltransferase (OPRT), an enzyme needed for the biosynthesis of pyrimidine nucleotides. Oxonic acid potassium catalyzes the phosphorylation of 5-fluorouracil (FF05372, BF166014) to 5-fluorouridine-5'-monophosphate (NF31487). In certain studies with rats, it has been shown that oxonic accid potassium suppresses the gastrointestinal toxicity of 5-fluorouracil or 5-FU without inhibiting the antitumor activity. Oxonic acid potassium, in combination with other prodrugs, boosts the antitumor activity and has shown positive results to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.

• Brand: Biosynth

Chemical properties

• Molecular weight: 195.17 g/mol
• Formula: C₄H₂KN₃O₄
• Purity: Min. 98 Area-%
• Color/Form: Powder