Proflavine hemisulfate

CAS: 1811-28-5

Ref. 3D-FP01535

Product Information

• Name: Proflavine hemisulfate
• Synonyms: 3,6-Diaminoacridine hemisulfate hydrate
• Brand: Biosynth
• Description: Proflavine hemisulfate is an antibiotic that inhibits bacterial growth by binding to DNA and inhibiting DNA synthesis. It binds to the dinucleotide phosphate of the bacterial ribosome and changes the shape of the nucleotide, preventing attachment of amino acids to form proteins. Proflavine hemisulfate also has a strong affinity for nuclear dna and is bound to it in a form that inhibits replication. The free form of proflavine is converted into enzyme form by phosphorylation, which inhibits protein synthesis and cell division. Proflavine hemisulfate has been shown to inhibit multidrug efflux pumps in bacteria, leading to increased susceptibility of bacteria to antibiotics. In addition, proflavine hemisulfate possesses inhibitory properties against transfer reactions in cells. The method used for measuring proflavine hemisulfate activity is electrochemical impedance spectroscopy (EIS) on cell nuclei suspensions in a model system.

Chemical properties

• Molecular weight: 258.29 g/mol
• Formula: C₁₃H₁₁N₃•(H₂SO₄)₀•(H₂O)x
• Purity: Min. 95%
• Color/Form: Powder