1-H-Pyrazole-3-carboxaldehyde

CAS: 3920-50-1

Ref. 3D-FP05874

Product Information

• Name: 1-H-Pyrazole-3-carboxaldehyde
• Synonyms: Pyrazol-3-carbaldehyde, 1H-pyrazole-3-carbaldehyde, 1H-Pyrazole-3-carboxaldehyde, 2H-Pyrazole-3-Carbaldehyde, Pyrazole-3-carboxaldehyde

Description

1-H-Pyrazole-3-carboxaldehyde (1HP) is a β-unsaturated ketone that has been shown to inhibit the growth of chronic pulmonary fungal infections, such as histoplasmosis, coccidioidomycosis, and blastomycosis. It has also been shown to have anticancer activity in vitro and in vivo. 1HP inhibits cellular proliferation by inducing cell cycle arrest at the G(2)/M checkpoint. The molecular mechanism of this inhibition is due to an increase in the expression of p21 protein and p27 protein, which are tumor suppressor proteins that regulate progression through the cell cycle. 1HP also inhibits HIV infection by inhibiting reverse transcriptase and proteases, which are enzymes involved in viral replication. This compound binds to active methylene groups on the enzyme's surface, blocking its ability to perform chemical reactions with other molecules. 1HP also has strong inhibitory effects on cancer cells because it causes structural

• Brand: Biosynth

Chemical properties

• Molecular weight: 96.09 g/mol
• Formula: C₄H₄N₂O
• Purity: Min. 95%