H-Pro-Val-OH

CAS: 52899-09-9

Ref. 3D-FP108165

Product Information

• Name: H-Pro-Val-OH
• Synonyms: 107: PN: WO2006024694 SEQID: 107 claimed protein, 147: PN: EP2161028 PAGE: 10 claimed protein, 34: PN: WO2014102101 SEQID: 334 claimed protein, 34: PN: WO2014102104 SEQID: 133 claimed protein, <span class="text-smallcaps">L</smallcap>-Prolyl-<smallcap>L</span>-valine, <span class="text-smallcaps">L</smallcap>-Valine, <smallcap>L</span>-prolyl-, <span class="text-smallcaps">L</smallcap>-Valine, N-<smallcap>L</span>-prolyl-, L-Propyl-L-valine, N-propyl-L-valine, NSC 319054, Prolyl-valine, Prolylvaline, Valine, N-<span class="text-smallcaps">L</span>-prolyl-
• CAS: 52899-09-9

Description

H-Pro-Val-OH is an amide that is used to treat renal disorders by inhibiting leukocyte elastase. It has been shown to be a potent inhibitor of serine proteases, including chymotrypsin and trypsin. H-Pro-Val-OH binds to the active site on serine proteases and blocks the release of peptides from the enzyme. The binding constant for H-Pro-Val-OH with chymotrypsin was found to be in the range of 3 x 10 M, which is significantly higher than that for other amides. In addition, H-Pro-Val-OH inhibits cytolysis by lysosomal enzymes and protects against liver injury caused by chronic liver disease. This drug also shows low molecular weight and high water solubility, making it effective in treating acute hepatitis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 214.26 g/mol
• Formula: C₁₀H₁₈N₂O₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C10H18N2O3/c1-6(2)8(10(14)15)12-9(13)7-4-3-5-11-7/h6-8,11H,3-5H2,1-2H3,(H,12,13)(H,14,15)/t7-,8-/m0/s1
• InChI key: InChIKey=AWJGUZSYVIVZGP-YUMQZZPRSA-N
• SMILES: CC(C)[C@H](NC(=O)[C@@H]1CCCN1)C(=O)O