Polyphyllin B (Formosanin C)

CAS: 50773-42-7

Ref. 3D-FP145263

Product Information

• Name: Polyphyllin B (Formosanin C)
• Synonyms: (25R)-Spirost-5-en-3β-ol 3-O-α-<span class="text-smallcaps">L</smallcap>-rhamnopyranosyl-(1-2)-O-[[α-<smallcap>L</smallcap>-rhamnopyranosyl-(1-4)]-O-[α-<smallcap>L</smallcap>-rhamnopyranosyl-(1-4)]]-β-<smallcap>D</span>-glucopyranoside, (3beta,14xi,25R)-spirost-5-en-3-yl 6-deoxy-alpha-L-glucopyranosyl-(1->4)-6-deoxy-alpha-L-mannopyranosyl-(1->4)-[(4xi)-6-deoxy-alpha-L-lyxo-hexopyranosyl-(1->2)]-beta-D-glucopyranoside, (3β,25R)-Spirost-5-en-3-yl O-6-deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→4)-6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→4)]-β-<smallcap>D</span>-glucopyranoside, 17-Deoxyparis VII, Asperin, Diosgenin 3-O-α-<span class="text-smallcaps">L</smallcap>-rhamnopyranosyl-(1→2)-[α-<smallcap>L</smallcap>-rhamnopyranosyl-(1→4)-α-<smallcap>L</smallcap>-rhamnopyranosyl-(1→4)]-β-<smallcap>D</span>-glucopyranoside, Diosgenin 3-O-α-<span class="text-smallcaps">L</smallcap>-rhamnopyranosyl-(1→4)-α-<smallcap>L</smallcap>-rhamnopyranosyl-(1→4)-[α-<smallcap>L</smallcap>-rhamnopyranosyl-(1→2)]-β-<smallcap>D</span>-glucopyranoside, Formosanin C, NSC 306864, Paridis saponin II, Paris II, Paris saponin II, Parissaponin P_b, Parrisaponin, Saponin P-d, from Alliumfistulosum, Saponin Pb, β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→4)-6-deoxy-α-<smallcap>L</span>-mannopyranosyl-(1→4)]-
• CAS: 50773-42-7

Description

Polyphyllin B is a natural compound that is the main constituent of Formosanin C, which has been used in traditional Chinese medicine for centuries. Polyphyllin B inhibits the activity of DNA polymerase, thus inhibiting the transcription and replication of DNA. It also binds to the bcl-2 protein and inhibits apoptosis by blocking the activation of caspases. This drug also blocks tumor necrosis factor-α (TNF-α) from binding to its receptor on cells. The anti-cancer effects are due to its ability to inhibit cyclin D2 expression, which prevents the progression through G1 phase and into S phase. In addition, it has been shown to be effective against oxidative injury in a rat model of acute toxicity.

• Brand: Biosynth

Chemical properties

• Molecular weight: 1,015.19 g/mol
• Formula: C₅₁H₈₂O₂₀
• Purity: Min. 95%
• Color/Form: Powder