Phorbol-12-myristate-13-acetate

CAS: 16561-29-8

Ref. 3D-FP15184

Product Information

• Name: Phorbol-12-myristate-13-acetate
• Synonyms: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate, 1,6,8-Beta-Tetramethyl-L)-9A-Acetate9-Myristate, 12-O-Tetradecanoylphorbol 13-acetate, 12-O-Tetradecanoylphorbolacetate, 12-O-Tetradekanoylphorbol-13-Acetat, 12-Tetradecanoylphorbol 13-acetate, 12-Tetradecanoylphorbol 13-monoacetate, 12-Tetradecanoylphorbol13-Monoacetate, 13-O-Acetylphorbol 12-myristate, 1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv., 4β-Phorbol 12-myristate 13-acetate, Factor A1, Factor A1 (croton oil), Factor A₁, Factor A₁ (croton oil), Myristic acid, 9-ester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9a-acetate, (+)-, Nsc 262244, PMA, PMA (tumor promoter), Pd 616, Phorbol 12-tetradecanoate 13-acetate, Phorbol myristate acetate, TPA, TPA (phorbol derivative), Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester, Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-, Tetradecanoylphorbol acetate, β-Phorbol 12-myristate 13-acetate
• CAS: 16561-29-8

Description

Phorbol-12-myristate-13-acetate is a phorbol ester that inhibits the activity of protein kinase C. It binds to the response element on DNA and blocks RNA synthesis, leading to cell death. Phorbol 12-myristate 13-acetate has been shown to inhibit the proliferation of human squamous cells in culture, which may be caused by its ability to inhibit the cell cycle. This drug also has been shown to inhibit the production of cytokines such as interleukin-1β and tumor necrosis factor α (TNFα) in human polymorphonuclear leukocytes (PMNLs).

• Brand: Biosynth

Chemical properties

• Molecular weight: 616.83 g/mol
• Formula: C₃₆H₅₆O₈
• Purity: Min. 98 Area-%
• Color/Form: White Powder