Poloxamer 407

CAS: 9003-11-6

Ref. 3D-FP153270

Product Information

• Name: Poloxamer 407
• Synonyms: 333E, 50Mb-26X, 75H380000, 75H90000, 75Hb1440, 80De40U, Bloatguard, CE, Exocorpol, Kwc-Q, Magcyl, Nixolen, Oxalgon, PAG, Poloxalcol, Poloxalene, Poloxalkol, Polyoxyethylene-polyoxypropylene, Proksanol, Proxanol, Regulaid, Slovanik, Vepoloxamer, α-Hydro-ω-hydroxy-poly(oxyethylene)-poly(oxypropylene), Glycols, polyethylene-polypropylene, Oxirane, 2-methyl-, polymer with oxirane, Oxirane, polymer with methyloxirane, Oxirane, methyl-, polymer with oxirane, Propylene oxide, polymer with ethylene oxide

Description

Poloxamer 407 is a chemically stable, biocompatible polymer that is used in a number of medical applications. It has an optimum concentration at between 2 and 5% by weight. Poloxamer 407 has been shown to limit renal injury in animals during ischemia-reperfusion (I/R) injury, as well as reducing the bioavailability of certain drugs. It also exhibits thermoreversible behaviour, which means it can change from a liquid to a gel when heated and back again when cooled. The surface methodology is based on the solvency of the polymer and its ability to form hydrogen bonds with water molecules. Poloxamer 407 has been shown to reduce the thermoresponsiveness of skin grafts in vivo and increase drug absorption through nasal passages, making it suitable for use as a nasal drug delivery system.

• Brand: Biosynth

Chemical properties

• Formula: (C₃H₆O·C₂H₄O)x
• Purity: Min. 95%
• Color/Form: White Powder