(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

CAS: 128625-52-5

Ref. 3D-FP15550

Product Information

• Name: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
• Synonyms: PyBOP
• Brand: Biosynth
• Description: PyBOP is a phosphonium salt used as a coupling reagent for peptide synthesis. PyBOP is very efficient: high yields, low epimerisation and high conversion rates can be achieved. PyBOP generates an activated HOBt ester in situ, in the presence of a base such as triethylamine or Hünig’s base. PyBOP is the pyrrolidino derivative of the phosphonium coupling reagent BOP, which is equally efficient, but generates the extremely toxic and carcinogenic HMPA as a by-product in situ. PyBOP is generally preferred over BOP because it gives comparable performances but generates a less toxic by-product.

Chemical properties

• Molecular weight: 520.39 g/mol
• Formula: C₁₈H₂₈N₆OP·PF₆
• Purity: Min. 98 Area-%
• Color/Form: White Powder