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17-(3-Pyridyl)androsta-5,16-dien-3-one is a synthetic steroid that has been shown to inhibit the synthesis of androgens in prostate cancer cells. It acts by competitive inhibition of 3β-hydroxysteroid dehydrogenase, which is an enzyme that converts progesterone into 17α, 20α-dihydroprogesterone. This drug also inhibits the production of testosterone by binding to cytochromes P450 and prevents its conversion into dihydrotestosterone. The drug has been shown to be effective against resistant prostate cancer cells in vitro as well as in vivo models with ventral prostates. It also has anti-inflammatory properties due to its ability to inhibit prostaglandin synthesis and decrease the expression of inflammatory cytokines such as IL1β.
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