Product Information
- Benzene, ethoxy-
- Ethoxybenzene
- Ethyl Phenyl Ether
- Fenetol
- Nsc 406706
- Phenetol
- Phenoxyethane
- Phenyl Ethyl Ether
- Phenylcthylether:
Phenetole is an inhibitor of the sodium-dependent glucose transporter (SGLT) that is used to inhibit the uptake of glucose from the gut into the bloodstream. Phenetole has been shown to decrease blood sugar levels in patients with metabolic disorders such as type 2 diabetes. The inhibition of SGLT by phenetole is competitive and reversible, and it does not bind to insulin receptors or other cell membrane proteins. Phenetole binds to a groove on the SGLT protein that is located at the interface between two subunits of the transporter. The binding site for phenetole has been identified as a hydrophobic pocket in which there are several hydroxyl groups and a single methyl ethyl group. The hydroxyl groups may interact with hydrogen bonding partners on the nearby amino acid residues, while the methyl ethyl group occupies a position where it can be hydrogen-bonded to an oxygen atom in one of these amino acids. This binding results in a conformational change
Chemical properties
Technical inquiry about: 3D-FP16118 Phenetole
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