1,2,3,7,8-Pentachlorodibenzo-p-dioxin

CAS: 40321-76-4

Ref. 3D-FP26796

Product Information

• Name: 1,2,3,7,8-Pentachlorodibenzo-p-dioxin
• Synonyms: 1,2,3,7,8-Pentachlorodibenzo[b,e][1,4]dioxin
• Brand: Biosynth
• Description: 1,2,3,7,8-Pentachlorodibenzo-p-dioxin is a polychlorinated dibenzodioxin that binds to the aryl hydrocarbon receptor (AhR) and activates gene transcription. It has been shown to disrupt the expression of genes that are involved in fatty acid synthesis and methyl transferase reactions. This compound also inhibits the activity of human serum enzymes such as β-hydroxybutyrate dehydrogenase and β-ketoacyl reductase. The AhR is a transcription factor that regulates the expression of many genes in response to toxic substances. The AhR protein is expressed in both humans and rats with its highest levels found in fatty tissues such as adipose tissue and liver. 1,2,3,7,8-Pentachlorodibenzo-p-dioxin is metabolized by cytochrome P450 enzymes into reactive intermediates that bind with DNA or

Chemical properties

• Molecular weight: 356.41 g/mol
• Formula: C₁₂H₃Cl₅O₂
• Purity: (%) Min. 85%
• Color/Form: Powder