Pentetic acid

CAS: 67-43-6

Ref. 3D-FP29951

Product Information

• Name: Pentetic acid
• Synonyms: DTPADiethylenetriaminepentaacetic acid, (Carboxymethylimino)bis(ethylenenitrilo)tetraacetic acid, 1,1,4,7,7-Diethylenetriaminepentaacetic acid, 2,2'-([(Carboxymethyl)Imino]Bis{Ethane-2,1-Diyl[(Carboxymethyl)Imino]})Diacetate (Non-Preferred Name), 2-[Bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid, 3,6,9-Triazaundecanedioic acid, 3,6,9-tris(carboxymethyl)-, Acetic acid, 2,2',2'',2'''-[[(carboxymethyl)imino]bis(2,1-ethanediylnitrilo)]tetrakis-, Acetic acid, 2,2′,2′′,2′′′-[[(carboxymethyl)imino]bis(2,1-ethanediylnitrilo)]tetrakis-, Carboxymethyliminobis(Ethylenenitrilo) Tetraacetic Acid, Chel 330 acid, Chel DTPA, Chelest 3PA, Chelest PA, Chelest PA-SD, Clewat DA, Complexon V, Dabeersen 503, Detapac, Detarex, Detp, Detpa, Diaethylentriamin-N,N,N',N'',N''-Pentaessigsaeure, Diethylene triamine pentaacetic acid, Diethylenetriamine pentaacetic acid, Diethylenetriamine-N,N,N',N'',N''-pentaacetic acid, Diethylenetriaminepentaacetic Acid (Dtpa), Diethylenetriamino pentaacetic acid, Diethylentriaminopentacetic Acid, Dissolvine D, Dpta, Dtpa, Dtpa Acid, Glycine, N,N'-Bis[2-[Bis(Carboxymethyl)Amino]Ethyl]-, Hamp-Ex Acid, Idranal?V, Monaquest CAI, N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine, N-(2-aminoethyl)ethane-1,2-diamine acetate (1:5), N-Carboxymethyliminobis(ethylennitrilo)tetraessigsaure, N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid), Nsc 7340, Pentacarboxymethyl diethylenetriamine, Titriplex V, Trilon CS, [(2-[[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino]-ethyl)-carboxymethyl-amino]-acetic acid, [[(Carboxymethyl)imino]bis(ethylenenitrilo)]tetraacetic acid, acide N-carboxymethyliminobis(ethylenenitrilo)tetraacetique, acido N-carboximetiliminobis(etilennitrilo)tetraacetico

Description

Pentetic acid, also known as DTPA, is an organic compound that act as metal chelator or radioligand for diagnosis applications. It binds to prostate receptors and has been shown to have tumor treatment properties by inhibiting prostate cancer cell growth and inducing apoptosis. DTPA has a high affinity to radiactive metals (lutetium (Lu-117), gallium (Ga-67), indium (In-111), yttrium (Y-90), gadolinium (Gd(III)) and yttrium (Y(III)) which makes the conjugate being really useful for MRI contrast imaging and radiolabeling. DTPA, as similar compounds like, NOTA, DOTA and TETA, is used as radionuclide when binding to integrin receptors on the surface of cancer cells. Pentetic acid has been shown to have anti-tumour effects against squamous carcinoma cells in vitro and to inhibit the activity of enzymes involved in inflammation, such as cyclooxygenase-2 (COX-2), lipoxygenase, and phospholipase A2. Pentetic acid also inhibits the synthesis of prostaglandins and leukotrienes.

• Brand: Biosynth

Chemical properties

• Molecular weight: 393.35 g/mol
• Formula: C₁₄H₂₃N₃O₁₀
• Purity: Min 98%
• Color/Form: Powder