Pamidronic acid

CAS: 40391-99-9

Ref. 3D-FP32121

Product Information

• Name: Pamidronic acid
• Synonyms: (3-Amino-1-Hydroxypropane-1,1-Diyl)Bis(Phosphonic Acid), (3-Amino-1-Hydroxypropylidene)Bisphosphonic Acid, (3-Amino-1-hydroxy-1-phosphonopropyl)phosphonic acid, (3-Amino-1-hydroxypropyliden)bisphosphonsaure, (3-Amino-1-hydroxypropylidene)-1,1-bisphosphonate, (α-Hydroxy-γ-aminopropylidene)diphosphonic acid, 1-Hydroxy-3-aminopropane-1,1-diphosphonic acid, 3-Amino-1-hydroxypropane-1,1-diphosphonic acid, 3-Amino-1-hydroxypropylidene-1,1-bisphosphonic acid, 3-Amino-1-hydroxypropylidenediphosphonic acid, ADP, AHPrBP, Acide (3-Amino-1-Hydroxypropylidene)Bisphosphonique, Acido (3-Amino-1-Hidroxipropiliden)Bisfosfonico, Amidronic acid, Bph 5, P,P′-(3-Amino-1-hydroxypropylidene)bis[phosphonic acid], Panolin, Phosphonic acid, P,P'-(3-amino-1-hydroxypropylidene)bis-, Propane-1-hydroxy-3-amino-1,1-diphosphonic acid, Pamidronate, Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-

Description

Pamidronic acid is a monosodium salt that inhibits the production of proteins by binding to the enzyme protein phosphatase. It has been shown to be an effective chemotherapeutic treatment in a number of animal models and human clinical trials for various cancers, including myeloma, squamous carcinoma, and bone cancer. Pamidronic acid also prevents the proliferation of tumor cells in culture via inhibition of DNA synthesis and RNA synthesis. This drug binds to estrogen receptors on the surface of some cancer cells, thereby inhibiting their response to estradiol benzoate (EB) stimulation. This leads to decreased tumor growth in preclinical models.

• Brand: Biosynth

Chemical properties

• Molecular weight: 235.07 g/mol
• Formula: C₃H₁₁NO₇P₂
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
• InChI key: InChIKey=WRUUGTRCQOWXEG-UHFFFAOYSA-N
• SMILES: NCCC(O)(P(=O)(O)O)P(=O)(O)O