1,10-Phenanthroline monohydrate

CAS: 5144-89-8

Ref. 3D-FP34903

Product Information

• Name: 1,10-Phenanthroline monohydrate
• Synonyms: 1,10-Phenanthroline 1,10-Phenanthroline hydrate E2
• Brand: Biosynth
• Description: 1,10-Phenanthroline monohydrate is a metal chelate that binds to DNA by hydrogen bonds. It has been shown to have an intramolecular hydrogen and a linear calibration curve with a coefficient of determination (r2) of 0.998. The rate constant for the reaction of 1,10-phenanthroline monohydrate with DNA is 5.00 x 10 M-1 s-1 at 25°C in water and pH 7.4 buffer. The coordination geometry for 1,10-phenanthroline monohydrate is octahedral with the axial ligands occupying the equatorial positions and the equatorial ligands occupying the axial positions. This compound has been shown to be active against HL-60 cells, which causes cancerous transformations in vitro. Fluorescence spectrometry data shows that 1,10-phenanthroline monohydrate can bind to DNA in vitro but not in vivo.

Chemical properties

• Molecular weight: 198.22 g/mol
• Formula: C₁₂H₁₀N₂O
• Purity: Min. 95%
• Color/Form: Off-White Powder