Phentolamine

CAS: 50-60-2

Ref. 3D-FP37047

Product Information

• Name: Phentolamine
• Synonyms: 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl-(4-methylphenyl)-amino]phenol, 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline, 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline, 2-[[N-(m-Hydroxyphenyl)-p-toluidino]methyl]-2-imidazoline, 3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(p-tolyl)amino)phenol, 3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-tolyl-amino]-phenol, 3-[(4,5-Dihydro-1H-imidazol-3-ium-2-ylmethyl)(4-methylphenyl)amino]benzenolate, 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol, C 7337, C 7337 Ciba, Dibasin, Fentolamina, Fentolamine, Phenol, m-[N-(2-imidazolin-2-ylmethyl)-p-toluidino]-, Phentolamin, Regitin, Regitine

Description

Phentolamine is a cyclase inhibitor and a drug that is used to treat high blood pressure. It is also used in the diagnosis of primary pulmonary hypertension. Phentolamine blocks the conversion of l-phenylalanine to tyrosine, which prevents the production of catecholamines such as dopamine, epinephrine, and norepinephrine. This drug has been shown to improve brain functions when administered to rats with Parkinson's disease. Phentolamine is prepared by reacting phenylmethylsulfonyl fluoride with phentolamine mesylate. The reaction produces phentolamine mesylate sodium salt.

• Brand: Biosynth

Chemical properties

• Molecular weight: 281.36 g/mol
• Formula: C₁₇H₁₉N₃O
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
• InChI key: InChIKey=MRBDMNSDAVCSSF-UHFFFAOYSA-N
• SMILES: Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1