Product Information
- N1-(4-Chlorophenyl)-N5-isopropylbiguanideN-(4-Chlorophenyl)-N'-isopropylimidodicarbonimidic diamide
- 1-(4-Chlorophenyl)-5-Isopropylbiguanide
- 1-(p-Chlorophenyl)-5-isopropylbiguanide
- 1-Isopropyl-5-(4-chlorophenyl)biguanide
- Biguanide, 1-(p-chlorophenyl)-5-isopropyl-
- Bigumal
- Chlorguanid
- Chlorguanide
- Chloroguanide
- Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
- See more synonyms
- Ips 07004
- N-(4-Chlorophenyl)-N′-(1-methylethyl)imidodicarbonimidic diamide
- N1-p-Chlorophenyl-N5-isopropylbiguanide
- N<sup>1</sup>-p-Chlorophenyl-N<sup>5</sup>-isopropylbiguanide
- Paludrin
- Proguanil hydrochloride
Proguanil is a drug that belongs to the class of p450 inhibitors. It is used to prevent and treat malaria, especially in areas where resistance to chloroquine has emerged. Proguanil inhibits microbial growth by inhibiting the activity of the enzyme p450, which is involved in the synthesis of cholesterol and other sterols. This inhibition prevents the production of these compounds, which are necessary for bacterial cell walls. Proguanil also blocks lymphocyte transformation and polymerase chain reactions (PCR) by binding to DNA-dependent RNA polymerase. Proguanil has been shown to be effective against infectious diseases such as malaria, infectious diarrhoea, and typhoid fever. The drug has been shown to have pharmacokinetic properties that differ depending on the dose and duration of treatment, with a high clearance rate at low doses but a lower clearance rate at higher doses. Proguanil does not bind well to albumin or human erythrocytes,
Chemical properties
Technical inquiry about: 3D-FP41719 Proguanil
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