3D-FP45202 - piperacilloic-acid-pyruvic-urea

Impurity Piperacillin EP Impurity C
Stability Hygroscopic
Applications Monodecarboxy Piperacilloic Acid (Piperacillin EP Impurity C) is an impurity of Piperacillin (P479950), a β-lactam antibiotic.
References Saikawa, I. et al.: Yakug. Zas., 97, 995 (1977); Saikawa, I. et al.: Yakug. Zas., 97, 1071 (1977); Takano, S. et al.: Yakug. Zas., 97, 1064 (1977);

Impurity Piperacillin EP Impurity B
Stability Hygroscopic, Temperature Sensitive
Applications Piperacilloic Acid (Piperacillin EP Impurity B) is a degradation product of Piperacillin (P479950), a new β-lactam antibiotic.
References Waxman, D.J., et al.: J. Biol. Chem., 255, 3964 (1980), Waley, S.G., et al.: Biochem. J., et al.: 205, 631 (1982),

Stability Hygroscopic
Applications Piperacilloic Acid-Piperacillin Dimer Disodium Salt is Piperacillin (P479950) impurity and can be obtained from it. Piperacillin (P479950) is broad spectrum semi-synthetic antibiotic related to Penicillin. Antibacterial.
References Takai, A., et al.: Chemotherapy, 25, 816 (1977); Bodey, G.P., et al.: Antimicrob. Agents Chemother., 14, 78 (1978); Kuck, N.A., et al.: J. Antibiot., 31, 1175 (1978);

Applications (S)-α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]benzeneacetic Acid is an intermediate used in the synthesis of DL-Phenylglycyl)-piperacilloic Acid (P327400), which is a racemic degradation product of Piperacillin (P479950), a new β-lactam antibiotic.
References Waxman, D.J., et al.: J. Biol. Chem., 255, 3964 (1980), Waley, S.G., et al.: Biochem. J., et al.: 205, 631 (1982),

Piperacilloic acid is a synthetic compound that exhibits antibacterial activity. It has been shown to be effective against human pathogens, including urothelial carcinoma and human serum. Piperacilloic acid binds to the amino acids lysine and arginine in bacterial proteins and inhibits protein synthesis by inhibiting the function of enzymes that require these amino acids for their activity. The potency of piperacillin is low, but it is activated by hydrolysis in the acidic environment of the stomach or intestinal tract. Piperacilloic acid also has potential as a contraceptive agent because it may inhibit transcriptional regulation of genes that are involved in sperm production.