(+)-Pinoresinol

CAS: 487-36-5

Ref. 3D-FP65785

Product Information

• Name: (+)-Pinoresinol
• Synonyms: (+)-epi-Pinoresinol, 1H,3H-Furo[3,4-c]furan, phenol deriv., 4,4'-(1R,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2-methoxyphenol), 4,4'-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2-methoxyphenol), 4,4′-[(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2-methoxyphenol], NSC 35444, Phenol, 4,4′-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2-methoxy-, [1S-(1α,3aα,4α,6aα)]-, Phenol, 4,4′-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2-methoxy-, stereoisomer, d-Pinoresinol, phenol, 4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2-methoxy-, phenol, 4,4'-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2-methoxy-

Description

Pinoresinol is a natural compound that inhibits the activity of P-glycoprotein (P-gp) and toll-like receptor 4 (TLR4). It is also an inhibitor of DNA polymerase, with synergistic effects. Pinoresinol has been shown to have anti-inflammatory properties and has been used in the treatment of infectious diseases such as primary sclerosing cholangitis. In addition, it has been used for the treatment of neurodegenerative diseases such as Alzheimer's disease. Pinoresinol may be a useful therapeutic agent for the treatment of cancer.
Pinoresinol has shown strong antitumor activity against HL60 cells in vitro, which was associated with cell death by apoptosis. The IC50 values obtained were 0.5 μM for pinoresinol and 0.8 μM for ginsenoside Rg3 on hl-60 cells. Pinoresinol induced concentration-dependent cytotoxicity, with

• Brand: Biosynth

Chemical properties

• Molecular weight: 358.39 g/mol
• Formula: C₂₀H₂₂O₆
• Purity: Min. 97 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C20H22O6/c1-23-17-7-11(3-5-15(17)21)19-13-9-26-20(14(13)10-25-19)12-4-6-16(22)18(8-12)24-2/h3-8,13-14,19-22H,9-10H2,1-2H3/t13-,14-,19+,20+/m0/s1
• InChI key: InChIKey=HGXBRUKMWQGOIE-AFHBHXEDSA-N
• SMILES: COc1cc([C@H]2OC[C@@H]3[C@@H](c4ccc(O)c(OC)c4)OC[C@H]23)ccc1O