Pristimerin

CAS: 1258-84-0

Ref. 3D-FP73969

Product Information

• Name: Pristimerin
• Synonyms: 2-Picenecarboxylic acid, 1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-, methyl ester, (2R,4aS,6aS,12bR,14aS,14bR)-, 2-Picenecarboxylic acid, 1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-, methyl ester, [2R-(2α,4aβ,6aβ,12bβ,14aα,14bβ)]-, 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, methyl ester, (9β,13α,14β,20α)-, 24-Nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, methyl ester, Celastrol, methyl ester, Celastrol-methylether, D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, methyl ester, (20alpha)-, D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, methyl ester, (20α)-, Methyl 10-Hydroxy-2,4A,6A,9,12B,14A-Hexamethyl-11-Oxo-1,2,3,4,4A,5,6,6A,11,12B,13,14,14A,14B-Tetradecahydropicene-2-Carboxylate, NSC 99281, methyl (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylate

Description

Pristimerin is a natural product that inhibits the activity of the P-glycoprotein (P-gp), which is an efflux pump that exports drugs from cells. The inhibition of P-gp by pristimerin leads to increased accumulation of drugs at higher concentrations in the cells, which can lead to apoptosis. In addition, pristimerin has been shown to increase intracellular ATP levels and inhibit growth factor-β1. This synergistic effect may be useful for treating bowel disease and cancer.

• Brand: Biosynth

Chemical properties

• Molecular weight: 464.64 g/mol
• Formula: C₃₀H₄₀O₄
• Purity: Min. 95%
• Color/Form: Solid