Melflufen hydrochloride

CAS: 380449-54-7

Ref. 3D-FQA44954

Product Information

• Name: Melflufen hydrochloride
• Brand: Biosynth
• Description: Melflufen hydrochloride is a peptide-conjugated alkylating agent, which is a small molecule derived from the combination of melphalan and a peptide moiety. Its design targets malignant cells through an innovative mechanism involving enhanced lipophilicity, allowing the compound to more efficiently penetrate cell membranes. Once inside the cell, the peptide linkage is cleaved by aminopeptidases, predominantly in cancer cells due to their overexpression of such enzymes. This cleavage releases active melphalan, which then forms covalent bonds with DNA, leading to crosslinking and subsequent interruption of DNA replication and transcription, ultimately inducing cell apoptosis.The primary applications of Melflufen hydrochloride are in oncology, specifically targeting hematological malignancies such as multiple myeloma. Its targeted delivery system aims to minimize the systemic toxicity commonly associated with conventional alkylating agents, offering a potentially improved therapeutic index. Researchers are exploring its efficacy in various clinical settings to better understand its utility and refine its application in personalized medicine approaches for cancer patients.

Chemical properties

• Molecular weight: 534.9 g/mol
• Formula: C₂₄H₃₁Cl₃FN₃O₃
• Purity: Min. 95%