SB-649868

CAS: 380899-24-1

Ref. 3D-FQA89924

Product Information

• Name: SB-649868
• Brand: Biosynth
• Description: SB-649868 is a drug in clinical development for the treatment of sleep-wake disorders. It is a potent and selective allosteric modulator of the GABAA receptor, with a profile that includes high affinity for the α1β2γ2 subtype. SB-649868 has been shown to increase slow wave sleep and delta power during wakefulness in healthy human subjects. SB-649868 has also been shown to have no effect on blood pressure or heart rate at clinically relevant doses, suggesting reduced risk for cardiovascular side effects.SB-649868 was well tolerated in preclinical studies, without serious adverse events observed.

Chemical properties

• Molecular weight: 477.55 g/mol
• Formula: C₂₆H₂₄FN₃O₃S
• Purity: Min. 95%