Roflumilast N-oxide

CAS: 292135-78-5

Ref. 3D-FR27750

Product Information

• Name: Roflumilast N-oxide
• Synonyms: 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridinyl)-4-(difluoromethoxy)benzamideN-(3,5-Dichloro-1-oxopyridin-4-yl)-4-difluo romethoxy-3-cyclopropyl-methoxybenzamide, RofluMilast N-Oxide
• CAS: 292135-78-5

Description

Roflumilast N-oxide is a drug that is used to treat chronic obstructive pulmonary disease (COPD). It belongs to the group of drugs called phosphodiesterase-4 (PDE4) inhibitors. Roflumilast N-oxide inhibits the production of chemokines and reduces the recruitment of inflammatory cells, which improves lung function. Roflumilast N-oxide has been shown to reduce matrix metalloproteinases in vitro and in an experimental model in mice. In addition, roflumilast N-oxide has been shown to inhibit the transport of erythromycin into bronchial epithelial cells. The LC-MS/MS method is used for the determination of pharmacokinetic parameters for roflumilast N-oxide.

• Brand: Biosynth

Chemical properties

• Molecular weight: 419.21 g/mol
• Formula: C₁₇H₁₄Cl₂F₂N₂O₄
• Purity: Min. 95%
• InChI: InChI=1S/C17H14Cl2F2N2O4/c18-11-6-23(25)7-12(19)15(11)22-16(24)10-3-4-13(27-17(20)21)14(5-10)26-8-9-1-2-9/h3-7,9,17,25H,1-2,8H2
• InChI key: InChIKey=KHXXMSARUQULRI-UHFFFAOYSA-N
• SMILES: O=C(N=c1c(Cl)cn(O)cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1