Rottlerin

CAS: 82-08-6

Ref. 3D-FR29637

Product Information

• Name: Rottlerin
• Synonyms: (2E)-1-[6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-phenylprop-2-en-1-one, (2E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one, 2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)-, 2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (E)-, Acetophenone, 3'-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl)-2',4',6'-trihydroxy-5'-methyl-, Acetophenone, 3′-[(8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2′,4′,6′-trihydroxy-5′-methyl-, Brn 0070757, Kamalin, Mallotoxin, Nsc 56346, Nsc 94525, PKC-δ/PKC-θ inhibitor

Description

Rottlerin is a natural compound that inhibits the activity of MMP-9, an enzyme that degrades the extracellular matrix. It is also a potent inhibitor of autophagy and apoptosis, which are important for the development of cancer cells. Rottlerin binds to dinucleotide phosphate (DNP) and inhibits DNP-mediated transcriptional regulation. Rottlerin also has a chemical biology component to its mechanism of action due to its ability to bind to DNA. Rottlerin is currently being studied as a potential treatment for squamous carcinoma, in which it reduces tumor size by increasing apoptosis pathway activation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 516.54 g/mol
• Formula: C₃₀H₂₈O₈
• Purity: Min. 95 Area-%
• Color/Form: Orange Powder