Sarafotoxin C trifluoroacetate salt

CAS: 121695-87-2

Ref. 3D-FS110267

Product Information

• Name: Sarafotoxin C trifluoroacetate salt
• Synonyms: H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH H-CTCNDMTDEECLNFCHQDVIW-OH, Srtx-C, Sarafotoxin S6C (Atractaspis Engaddensis), Sarafotoxin S6C, Atractaspsis Engaddensis, Sarafotoxin 6C, Sarafotoxin C, Sarafotoxin C (Atractaspis Engaddensis), Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp

Description

Sarafotoxin C is a peptide from the venom of the spider Phoneutria nigriventer that has been shown to have potent inhibitory properties on endothelin-1. Sarafotoxin C is able to block intracellular Ca2+ levels and signal pathways, leading to decreased levels of endothelin-1 as well as other inflammatory mediators. Sarafotoxin C has also been shown to have an anti-inflammatory effect in bowel disease, which may be due to its ability to inhibit the production of cytokines and prostaglandins. The biological properties of sarafotoxin C are related to its inhibition of polymerase chain reaction (PCR) amplification of DNA. This inhibition is due to the binding of sarafotoxin C with endothelin receptors on DNA, which prevents DNA polymerase from attaching. Endothelin-a receptor activity can also be inhibited by sarafotoxin C through enzymatic inactivation. Sarafot

• Brand: Biosynth

Chemical properties

• Molecular weight: 2,515.76 g/mol
• Formula: C₁₀₃H₁₄₇N₂₇O₃₇S₅
• Purity: Min. 95%