Product Information
Name:SM-164
Brand:Biosynth
Description:SM-164 is a monoclonal antibody that targets the protein TNF-related apoptosis-inducing ligand (TRAIL), which is involved in the death of cancer cells. TRAIL induces apoptosis by binding to the TRAIL receptor 1 (TRAILR1) and activating caspase-8, -9, and -10. SM-164 has minimal toxicity and enhances the radiosensitizing effect of adriamycin. It also inhibits caspase activity by antagonizing TRAIL signaling. Structural analysis revealed that SM-164 binds to TRAIL with an affinity of 0.7 nM, resulting in inhibition of proteolytic cleavage and preventing activation of caspases. This inhibited proteolysis prevents degradation of cellular proteins, leading to cell death by apoptosis.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1,121.42 g/mol
Formula:C62H84N14O6
Purity:Min. 95%
Color/Form:Powder
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