Product Information
SM-164 is a monoclonal antibody that targets the protein TNF-related apoptosis-inducing ligand (TRAIL), which is involved in the death of cancer cells. TRAIL induces apoptosis by binding to the TRAIL receptor 1 (TRAILR1) and activating caspase-8, -9, and -10. SM-164 has minimal toxicity and enhances the radiosensitizing effect of adriamycin. It also inhibits caspase activity by antagonizing TRAIL signaling. Structural analysis revealed that SM-164 binds to TRAIL with an affinity of 0.7 nM, resulting in inhibition of proteolytic cleavage and preventing activation of caspases. This inhibited proteolysis prevents degradation of cellular proteins, leading to cell death by apoptosis.
Chemical properties
Technical inquiry about: 3D-FS137718 SM-164
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