Semustine

Ref. 3D-FS153233

Product Information

• Name: Semustine
• Brand: Biosynth
• Description: Semustine is an anti-cancer drug that belongs to the class of alkylating agents. It is a prodrug that is activated in the body by hydrolysis to the active form, methyl-CCNU. The drug has minimal toxicity and can be used as a model system for studying other anti-cancer drugs. Semustine has been shown to have minimal toxicity when administered orally or intravenously and has been used in experimental models of cancer. The drug also binds to DNA, forming covalent linkages with guanine bases, which prevents DNA synthesis and replication. Semustine is also a synthetic retinoid that can bind to specific regions of human serum albumin (HSA) and inhibit HSA function, which may be responsible for some of its toxic effects on humans.

Chemical properties

• Molecular weight: 247.72 g/mol
• Formula: C₁₀H₁₈ClN₃O₂
• Purity: Min. 95%
• InChI: InChI=1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)
• InChI key: InChIKey=FVLVBPDQNARYJU-UHFFFAOYSA-N
• SMILES: CC1CCC(NC(=O)N(CCCl)N=O)CC1