Z-Sulindac sulphide

CAS: 49627-27-2

Ref. 3D-FS27970

Product Information

• Name: Z-Sulindac sulphide
• Synonyms: Z-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid, (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid, (Z)-Sulindac sulfide, 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (Z)-, 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-, Sulindac sulfide, Sulindac sulfide, (Z)-, cis-Sulindac sulfide

Description

(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid is a potent inhibitor of protein synthesis. It has been shown to inhibit the activity of sulindac sulfide, a cyclase inhibitor and nonsteroidal anti-inflammatory agent, in human polymorphonuclear leukocytes and cancer cells. (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid also inhibits the mitochondrial membrane potential and reduces the growth of cancer cells by inhibiting proteins that are involved in cell proliferation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 340.41 g/mol
• Formula: C₂₀H₁₇FO₂S
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
• InChI key: InChIKey=LFWHFZJPXXOYNR-MFOYZWKCSA-N
• SMILES: CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1