Sciadopitysin

CAS: 521-34-6

Ref. 3D-FS65450

Product Information

• Name: Sciadopitysin
• Synonyms: Amentoflavone-7,4'4'''trimethylether, 3′′′,8-Biflavone, 5,5′′,7-trihydroxy-4′,4′′′,7′′-trimethoxy-, 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-, 5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-chromen-4-one, 7,4′,4′′′-Trimethylamentoflavone, Amentoflavone-7,4',4'''-trimethyl ether, Nsc 45108

Description

Sciadopitysin is a natural compound extracted from the plant Sciadopitys verticillata. It has been shown to have antioxidant and anti-inflammatory effects in vitro and in vivo. Sciadopitysin inhibits cytochrome P450 enzymes, which are responsible for metabolizing xenobiotics, including drugs. In rat liver microsomes, sciadopitysin competitively inhibited the enzyme p-hydroxybenzoate hydroxylase (PHAH), an enzyme that catalyzes the conversion of p-hydroxybenzoic acid to hydroxybenzoate. This inhibition results in increased levels of p-hydroxybenzoic acid, which may be responsible for sciadopitysin’s hepatotoxicity. Sciadopitysin also inhibits mitochondrial membrane potential and lysosomal function without affecting ATP levels.

• Brand: Biosynth

Chemical properties

• Molecular weight: 580.54 g/mol
• Formula: C₃₃H₂₄O₁₀
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C33H24O10/c1-39-18-7-4-16(5-8-18)27-15-25(38)32-23(36)13-22(35)30(33(32)43-27)20-10-17(6-9-26(20)41-3)28-14-24(37)31-21(34)11-19(40-2)12-29(31)42-28/h4-15,34-36H,1-3H3
• InChI key: InChIKey=YCXRBCHEOFVYEN-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(=O)c3c(O)cc(O)c(-c4cc(-c5cc(=O)c6c(O)cc(OC)cc6o5)ccc4OC)c3o2)cc1