Sakuranetin

CAS: 2957-21-3

Ref. 3D-FS66817

Product Information

• Name: Sakuranetin
• Synonyms: 4',5-Dihydroxy-7-methoxyflavanone, (-)-(S)-Sakuranetin, (2S)-2,3-Dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one, (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one, (S)-4′,5-Dihydroxy-7-methoxyflavanone, 4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (2S)-, 4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (S)-, 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one, 7-O-Methylnaringenin, Flavanone, 4′,5-dihydroxy-7-methoxy-, (S)-(-)-, Naringenin 7-O-methyl ether, Naringenin 7-methyl ether

Description

Sakuranetin is a flavonoid that has been shown to inhibit the methyltransferase activity of DNA methyltransferases (DNMTs). This property makes it an attractive chemotherapeutic agent for the treatment of skin cancer. Sakuranetin also has been shown to have antimicrobial properties against human pathogens, including methicillin-resistant Staphylococcus aureus and Helicobacter pylori. It does not have any effect on Escherichia coli or Salmonella typhimurium. In vitro assays show that sakuranetin inhibits the growth of 3T3-L1 preadipocytes, a cell line derived from mouse embryo fibroblasts, by inducing cell cycle arrest and apoptosis. Sakuranetin can also induce apoptosis in vitro in a model system using copper chloride as well as in an experimental model using mouse embryonic fibroblasts.

• Brand: Biosynth

Chemical properties

• Molecular weight: 286.28 g/mol
• Formula: C₁₆H₁₄O₅
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3
• InChI key: InChIKey=DJOJDHGQRNZXQQ-UHFFFAOYSA-N
• SMILES: COc1cc(O)c2c(c1)OC(c1ccc(O)cc1)CC2=O