4-Thiouracil

CAS: 591-28-6

Ref. 3D-FT02605

Product Information

• Name: 4-Thiouracil
• Synonyms: 2-Hydroxy-4-mercaptopyrimidine, Uracil, 4-thio-, 4-Thiopyrimidin-2-one, 2(1H)-Pyrimidinone, 3,4-dihydro-4-thioxo-, 3,4-Dihydro-4-thioxo-2(1H)-pyrimidinone

Description

4-Thiouracil is a uridine analog and has been shown to inhibit transcriptional regulation by hydrogen bonding with the dna template. 4-Thiouracil is a prodrug that is converted to its active form, thiouracil, which inhibits DNA synthesis and cell proliferation by inhibiting the enzyme topoisomerase II. This results in the formation of abnormal DNA molecules that are not replicated properly. Thiouracil also has photochemical properties due to its ability to absorb light at wavelengths below 400 nm. The photochemical properties of 4-thiouracil have been studied extensively as models for human tissue culture and the study of cancer cells.

• Brand: Biosynth

Chemical properties

• Molecular weight: 128.15 g/mol
• Formula: C₄H₄N₂OS
• Purity: Min. 97 Area-%
• Color/Form: Slightly Yellow Powder
• InChI: InChI=1S/C4H4N2OS/c7-4-5-2-1-3(8)6-4/h1-2H,(H2,5,6,7,8)
• InChI key: InChIKey=OVONXEQGWXGFJD-UHFFFAOYSA-N
• SMILES: O=c1[nH]ccc(=S)[nH]1