1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione

CAS: 568-72-9

Ref. 3D-FT09489

Product Information

• Name: 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione
• Synonyms: Tanshinone IIA, 1,6,6-Trimethyl-1,2,6,7,8,9-Hexahydrophenanthro[1,2-B]Furan-10,11-Dione, 1,6,6-Trimethyl-6,7,8,9-Tetrahydrophenanthro[1,2-B]Furan-10,11-Dione, 1,6,6-Trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione, 1,6-Dimethylphenanthro[1,2-B]Furan-10,11-Dione, 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione, Dan Shen Ketone, NSC 686519, Nsc 686518, Phenanthro(1,2-b)furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-, Salviol IIA, Tanshinon II, Tanshinone B, Tanshinone II, Tanshinone II A, Tashinone IIA

Description

1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione (TTD) is a plant compound that has been shown to have synergistic effects with tanshinone. TTD inhibits the enzyme glutathione peroxidase (GSH-Px), which is responsible for maintaining the balance of reactive oxygen species. TTD also induces proapoptotic proteins and causes neuronal death. This compound also has been shown to be an antiinflammatory agent in vivo and in vitro by inhibiting inflammatory mediators such as prostaglandin E2 and nitric oxide synthase. In addition to this effect on inflammation, TTD has been shown to inhibit glucose uptake in adipocytes. Furthermore, it can cause apoptosis through DNA binding activity in the human erythroleukemia cell line MIAPACA-2. It has also been

• Brand: Biosynth

Chemical properties

• Molecular weight: 294.34 g/mol
• Formula: C₁₉H₁₈O₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
• InChI key: InChIKey=HYXITZLLTYIPOF-UHFFFAOYSA-N
• SMILES: Cc1coc2c1C(=O)C(=O)c1c-2ccc2c1CCCC2(C)C