H-Thr-Phe-Leu-Leu-Arg-NH2

CAS: 197794-83-5

Ref. 3D-FT109632

Product Information

• Name: H-Thr-Phe-Leu-Leu-Arg-NH2
• Synonyms: TFLLRamide, (Thr¹)-TRAP-5 amide, TFLLR-NH2 Protease-Activated Receptor 1 (PAR1) Agonist(Thr1)-PAR-1 (1-5) amide (human)
• Brand: Biosynth
• Description: H-Thr-Phe-Leu-Leu-Arg-NH2 is a peptide that has been shown to reduce the severity of lung inflammation and injury in rats with pulmonary hypertension. It also prevents the release of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin 6 (IL6). This peptide also induces an antibody response against collagen gel, which is used to treat fibrotic diseases and wounds. The peptide binds to the soybean trypsin inhibitor, preventing it from inhibiting protease enzymes, thereby allowing for protein synthesis. H-Thr-Phe-Leu-Leu-Arg-NH2 has been shown to have antiapoptotic effects by restoring mitochondrial membrane potential in cancer cells. This peptide can be used as a therapeutic agent for various diseases including primary pulmonary hypertension, cancer tissues, and mitochondrial disorders.

Chemical properties

• Molecular weight: 647.81 g/mol
• Formula: C₃₁H₅₃N₉O₆
• Purity: Min. 95%
• Color/Form: White Powder