2-Thiobenzyl nicotinicacid

CAS: 112811-90-2

Ref. 3D-FT149842

Product Information

• Name: 2-Thiobenzyl nicotinicacid
• Synonyms: 2-[(Phenylmethyl)thio]-3-pyridinecarboxylicacid, 2-(Benzylsulfanyl)Pyridine-3-Carboxylic Acid, 2-(Phenylmethylthio)-3-pyridinecarboxylic acid, 2-Benzylsulfanyl-nicotinic acid, 2-Benzylsulfanylpyridine-3-carboxylic acid, 2-Thiobenzylnicotinic acid, 2-[(Phenylmethyl)thio]-3-pyridinecarboxylic acid, 3-Pyridinecarboxylic acid, 2-[(phenylmethyl)thio]-, Biphenyl-2-Ylboronic Acid, Ethyl 2-(Trifluoromethyl)Pyridine-3-Carboxylate

Description

2-Thiobenzyl nicotinic acid is a synthetic compound that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. It is used in the treatment of tuberculosis. 2-Thiobenzyl nicotinic acid is synthesized from 2-chloronicotinic acid, which is prepared by reacting benzyl chloride and hydrazine. The synthesis process can be divided into two steps: first, the benzyl chloride reacts with hydrazine to form an intermediate, which undergoes an acid-catalyzed hydrolysis to produce 2-chloronicotinic acid; second, the 2-chloronicotinic acid reacts with thiourea to form 2-thiobenzyl nicotinic acid. It has been shown that this compound inhibits fungal and bacterial growth at concentrations of 10 μM or less.

• Brand: Biosynth

Chemical properties

• Molecular weight: 245.3 g/mol
• Formula: C₁₃H₁₁NO₂S
• Purity: Min. 95%
• InChI: InChI=1S/C13H11NO2S/c15-13(16)11-7-4-8-14-12(11)17-9-10-5-2-1-3-6-10/h1-8H,9H2,(H,15,16)
• InChI key: InChIKey=OJNZDGDYAXCHPB-UHFFFAOYSA-N
• SMILES: O=C(O)c1cccnc1SCc1ccccc1