(+/-)-Thalidomide

CAS: 50-35-1

Ref. 3D-FT15648

Product Information

• Name: (+/-)-Thalidomide
• Brand: Biosynth
• Description: Classified as immunomodulatory drug, thalidomide suppresses the expression of tumor necrosis factor-alpha (TNF-α), interferes with a cascade of pro-inflammatory cytokines, and interferes with the secretion of vascular endothelial growth factor (VEGF) and beta fibroblast growth factor (bFGF). Similarly to apremilast, thalidomide carries a phthalimide ring, together with a glutarimide ring that is specifically recognized by the target molecule cereblon. Thanks to its ability to contrast neoangiogenesis and the modifications of the bone marrow stromal microenvironment, thalidomide is a powerful tool to fight hematologic cancers. In the treatment of SARS-CoV-2, the immunomodulatory and anti-inflammatory action of thalidomide has and has proved beneficial when combined with a low-dose glucocorticoid.

Chemical properties

• Molecular weight: 258.23 g/mol
• Formula: C₁₃H₁₀N₂O₄
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
• InChI key: InChIKey=UEJJHQNACJXSKW-UHFFFAOYSA-N
• SMILES: O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1