(+/-)-Taxifolin

CAS: 24198-97-8

Ref. 3D-FT28010

Product Information

• Name: (+/-)-Taxifolin
• Synonyms: Dihydroquercetin3,3',4',5,7-Pentahydroxyflavanone hydrate, (?à)-Dihydroquercetin, (?à)-Taxifolin, (±)-Dihydroquercetin, (±)-Taxifolin, 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, trans-(±)-, 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, trans-(?à)- (8CI), rel-(2R,3R)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-rel-

Description

Taxifolin is a natural compound that belongs to the class of flavonoids, which have shown hypoglycemic effects in experimental models. Taxifolin promotes apoptosis by inhibiting the expression of the BCL-2 protein. This protein inhibits apoptosis by binding to the pro-apoptotic proteins, such as p53 and Bax. Taxifolin also has anti-inflammatory properties due to its inhibition of prostaglandin synthesis. The optimum concentration for taxifolin is between 1 and 5 μM. It also binds to DNA-binding response elements, which may affect gene transcription. The rate constant for this process is approximately 10^(-4) M^{-1} s^{-1}. Taxifolin has been shown to be effective against dextran sulfate sodium (DSS)-induced inflammation in vivo, which may be due to its ability to inhibit postprandial blood glucose levels at a concentration of 5 mg/kg body weight.

• Brand: Biosynth

Chemical properties

• Molecular weight: 304.25 g/mol
• Formula: C₁₅H₁₂O₇
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
• InChI key: InChIKey=CXQWRCVTCMQVQX-LSDHHAIUSA-N
• SMILES: O=C1c2c(O)cc(O)cc2O[C@H](c2ccc(O)c(O)c2)[C@H]1O