Tolnaftate

CAS: 2398-96-1

Ref. 3D-FT28308

Product Information

• Name: Tolnaftate
• Synonyms: N-Methyl-N-(3-methylphenyl)carbamothioic acid O-2-naphthalenyl esterMethyl(3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester 2-Naphthyl N-methyl-N-(3-tolyl)thiocarbamate, 2-Naphthyl N-methyl-N-(3-tolyl)thiocarbamate, 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate, 2-Naphthyl N-methyl-N-m-tolylthiocarbamate, Aftate, Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl ester, Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester, Carbanilic acid, m,N-dimethylthio-, O-2-naphthyl ester, Chinofungin, Dermoxin, Dr. Scholl's Athlete's Foot Spray, Dungistop, Focusan, Hi-Alarzin, Methyl(3-methylphenyl)carbamothioic acid O-2-naphthaleneyl ester, Naphthiomate T, Nsc 233648, O-2-Naphthyl m,N-dimethylthiocarbanilate, O-2-naphthyl N,3-dimethyl(thiocarbanilate), O-Naphthalen-2-yl N-methyl-N-(3-methylphenyl)thiocarbamate, O-naphthalen-2-yl methyl(3-methylphenyl)carbamothioate, Phytoderm, Pitrex, Sch 10144, Sporiline, Timoped, Tinactin, Tinaderm, Tineacure, Tniaderm, Tolaftate, Tolnaftat, Tolnaftato, Tolnaphthate, Tolsanil, Tonoftal, Tritin

Description

Tolnaftate is a synthetic, broad-spectrum antifungal drug that has been used for the treatment of various types of fungal infections. Tolnaftate is believed to work through inhibition of the synthesis of ergosterol, which is an important component in fungal cell membranes. It can be applied topically or taken orally. Tolnaftate has been shown to have a low toxicity profile and does not appear to cause any significant side effects. In vitro studies using methyl ethyl cellulose and model systems such as Saccharomyces cerevisiae have shown that tolnaftate exhibits antifungal activity against a wide variety of fungi, including Candida albicans and Cryptococcus neoformans. To determine its efficacy in vivo, a study was conducted using mice with chronic dry eye disease as an experimental model. The results showed that tolnaftate reduced the disease activity score by about 50%. Tolnaftate also inhibits multid

• Brand: Biosynth

Chemical properties

• Molecular weight: 307.41 g/mol
• Formula: C₁₉H₁₇NOS
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
• InChI key: InChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N
• SMILES: Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1