Product Information
- (3a,5b,7a,12a)-Cholestane-3,7,12-triol3a,7a,12a-Trihydroxycoprostane
Trihydroxycoprostane is a natural compound and metabolite of cholesterol. It is produced by the microsomal cytochrome P450 enzymes in the liver, where it is converted to dihydroxycoprostane. Trihydroxycoprostane has been found to be a precursor of acid formation in humans, which may be due to its conversion to p-hydroxyphenylacetaldehyde and then to p-hydroxyphenylacetic acid. The uptake, metabolism and excretion of trihydroxycoprostanes have been studied in human liver cells and rat liver microsomes. This study found that trihydroxycoprostanes are metabolized by 3β-HSD or 3α-HSD and converted into dihydroxycoprostanes. Trihydroxycoprostane has also been shown to increase serum levels of alanine and urea nitrogen, but does not affect cholesterol levels in rats with cerebrotendinous xanthomat
Chemical properties
Technical inquiry about: 3D-FT28498 Trihydroxycoprostane
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