TFFH

CAS: 164298-23-1

Ref. 3D-FT35332

Product Information

• Name: TFFH
• Synonyms: Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate, Methanaminium, N-[(dimethylamino)fluoromethylene]-N-methyl-, hexafluorophosphate(1-), Methanaminium, N-[(dimethylamino)fluoromethylene]-N-methyl-, hexafluorophosphate(1-) (1:1), N-((Dimethylamino)fluoromethylene)-N-methylmethanaminium hexafluorophosphate, N-[(dimethylamino)(fluoro)methylidene]-N-methylmethanaminium, N-[(dimethylamino)(fluoro)methylidene]-N-methylmethanaminium hexafluorophosphate, Nitrogen(2+), [(fluoroamino)carbonyl]tetramethyl-, hexafluorophosphate(1-) (1:2), Tetramethylfluoroformamidinium hexafluorophosphate, TetramethylfluoroformamidiniumHexafluorophosphate, Tffh, [(Dimethylamino)(fluoro)methylidene]dimethylazanium; hexafluoro-λ5-phosphanuide

Description

TFFH is a fluoroformamidinium salt used as a coupling reagent for amide formation and peptide synthesis. TFFH is a non-hygroscopic and stable salt, readily available, affordable and efficient. TFFH allows high yields in liquid and solid phase, in presence of sterically hindered carboxylic acids and hindered or electron-deficient amines, with minimum racemisation. The carboxylic acid is activated by TFFH forming the more reactive acyl fluoride, which is reportedly less prone to racemisation than the corresponding acyl chloride.

• Brand: Biosynth

Chemical properties

• Molecular weight: 264.12 g/mol
• Formula: C₅H₁₂FN₂·F₆P
• Purity: Min. 98 Area-%
• Color/Form: White Off-White Powder