p-Toluenesulfonyl hydrazide

CAS: 1576-35-8

Ref. 3D-FT35432

Product Information

• Name: p-Toluenesulfonyl hydrazide
• Synonyms: (4-Methylphenylsulfonyl)hydrazine, (4-Tolylsulfonyl)hydrazide, (p-Tolylsulfonyl)hydrazine, 4-Methylbenzene-1-sulfonohydrazide, 4-Methylbenzenesulfonhydrazide, 4-Methylbenzenesulfonic acid hydrazide, 4-Methylbenzenesulfonohydrazide, 4-Methylbenzenesulfonyl hydrazide, 4-Methylphenylsulfonyl hydrazide, 4-Toluenesulfonic acid hydrazide, 4-Toluenesulfonohydrazine, Cellmic AH, Cellmic H, Cellmic K, Celogen TSH, Genitron PTS, N-Tosylhydrazine, Nsc 18715, Porofor TSH, Porofor TSH 75, Toluene-4-Sulfonyl Hydrazide, Toluene-4-Sulphonohydrazide, Toluene-4-sulfonohydrazide, Toluene-4-sulphonyl hydrazide, Tolueno-4-Sulfonohidrazida, Toluol-4-sulfonohydrazid, Tosylhydrazide, Tosylhydrazine, Unifor H, Unifor NH 500, p-Methylbenzenesulfonic acid hydrazide, p-Methylbenzenesulfonylhydrazine, p-Methylphenylsulfonylhydrazine, p-Toluenesulfonhydrazide, p-Toluenesulfonic acid, hydrazide, p-Toluenesulfonic hydrazide, p-Toluenesulfonohydrazide, p-Toluenesulfonylhydrazide, p-Toluenesulfonylhydrazine, p-Tolylsulfonyl hydrazide, p-Tosyl hydrazide, p-Tosylhydrazine

Description

p-Toluenesulfonyl hydrazide is a potent inhibitor of sugar transport. p-Toluenesulfonyl hydrazide binds to the basic protein and blocks the binding site for ATP, which is necessary for sugar transport. It also inhibits transcriptional regulation by interacting with RNA polymerase, preventing transcription and replication. This drug has been shown to be more effective than trifluoroacetic acid in inhibiting sugar transport in wild-type strains of bacteria, but less effective than trifluoroacetic acid in mutant strains of bacteria that lack an active ABC transporter system.

p-Toluenesulfonyl hydrazide is a white solid that can dissolve in polar solvents such as water and ethanol. The compound has been shown to be stable at pH 2-6, but decomposes at pH 7 or higher due to protonation of the nitrogen atom. p-Toluenesulfonyl hydrazide

• Brand: Biosynth

Chemical properties

• Molecular weight: 186.23 g/mol
• Formula: C₇H₁₀N₂O₂S
• Purity: Min. 95%
• Color/Form: White/Off-White Solid
• InChI: InChI=1S/C7H10N2O2S/c1-6-2-4-7(5-3-6)12(10,11)9-8/h2-5,9H,8H2,1H3
• InChI key: InChIKey=ICGLPKIVTVWCFT-UHFFFAOYSA-N
• SMILES: Cc1ccc(S(=O)(=O)NN)cc1