Tetraphenylphosphonium bromide

CAS: 2751-90-8

Ref. 3D-FT37719

Product Information

• Name: Tetraphenylphosphonium bromide
• Brand: Biosynth
• Description: Tetraphenylphosphonium bromide (TPB) is a quaternary ammonium salt that inhibits bacterial growth. TPB is a membrane-active agent that interacts with the cell nucleus and alters the properties of DNA in the mitochondria. It has shown efficacy against various antimicrobial agents, including antibiotics, by interfering with their transport across the cell membrane. The optimal concentration of TPB is 25-50 μM, which shows the best effect on bacterial growth. In addition to its antimicrobial activity, TPB also has been shown to inhibit drug transporters, such as P-glycoprotein and MRP1, which are involved in transporting drugs out of cells.

Chemical properties

• Molecular weight: 419.29 g/mol
• Formula: C₂₄H₂₀BrP
• Color/Form: Powder