4-(Trifluoromethyl)-L-phenylalanine

CAS: 114926-38-4

Ref. 3D-FT43466

Product Information

• Name: 4-(Trifluoromethyl)-L-phenylalanine
• Synonyms: (S)-2-Amino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid, Rarechem Bk Pt 0139, 4-(Trifluoromethyl)-L-Phenylalanine, L-3-[4-(Trifluoromethyl)Phenyl]Alanine, L-4-Trifluoromethylphe, H-Phe(4-Cf 3)-Oh, H-L-Phe(4-Trifluoromethyl)-Oh, H-Phe(4-CF3)-OH

Description

4-(Trifluoromethyl)-L-phenylalanine (4-TFMP) is an acyltransferase inhibitor that prevents the formation of fatty acids by inhibiting the enzyme ketoreductase. 4-TFMP has been shown to inhibit protein synthesis in myeloid leukemia cells and to have a cytotoxic effect on cancer cells. It also inhibits the growth of bacteria such as Salmonella enterica and Mycobacterium tuberculosis. In addition, 4-TFMP is used to treat infectious diseases such as tuberculosis, as well as metabolic disorders and some types of enzyme deficiencies. 4-TFMP is stereoselective and binds only to one type of acyltransferase, which is not present in humans.

• Brand: Biosynth

Chemical properties

• Molecular weight: 233.19 g/mol
• Formula: C₁₀H₁₀F₃NO₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C10H10F3NO2/c11-10(12,13)7-3-1-6(2-4-7)5-8(14)9(15)16/h1-4,8H,5,14H2,(H,15,16)/t8-/m0/s1
• InChI key: InChIKey=CRFFPDBJLGAGQL-QMMMGPOBSA-N
• SMILES: N[C@@H](Cc1ccc(C(F)(F)F)cc1)C(=O)O